EKPD: a hierarchical database of eukaryotic protein kinases and protein phosphatases

EKPD: a hierarchical database of eukaryotic protein kinases and protein phosphatases

We present here EKPD (http://ekpd.biocuckoo.org), a hierarchical database of eukaryotic protein kinases (PKs) and protein phosphatases (PPs), the key molecules responsible for the reversible phosphorylation of proteins that are involved in almost all aspects of biological processes. As extensive experimental and computational efforts have been carried out to identify PKs and PPs, an integrative...

Inhibitors of protein kinases and phosphatases.

Inhibitors of eukaryotic protein kinases and phosphatases are a chemically diverse array of natural and synthetic compounds, including medicines, potions and poisons. These substances are valuable pharmacological probes and affinity ligands for the kinases and phosphatases of signalling pathways, enhancing our knowledge of the cellular effects of the pathway in question. More broadly, this basi...

Phosphoregulators: protein kinases and protein phosphatases of mouse.

With the completion of the human and mouse genome sequences, the task now turns to identifying their encoded transcripts and assigning gene function. In this study, we have undertaken a computational approach to identify and classify all of the protein kinases and phosphatases present in the mouse gene complement. A nonredundant set of these sequences was produced by mining Ensembl gene predict...

Regulation and Function of Protein Kinases and Phosphatases

1Department of Biochemistry &Molecular Biology, Bio21Molecular Sciences and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia 2Department of Biochemistry, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China 3Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish Ge...

Ca/calmodulin-dependent protein kinases: physiological and pharmacological significance of protein phosphatases Running title: CaMK-regulating protein phosphatases